首页> 外文OA文献 >HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy

【2h】

HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy

机译：跃升为跃点：募集I类组蛋白脱乙酰基酶可阻止与心脏肥大相对应的新型转录途径

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Histone acetylation, regulated by two antagonistic enzymes — histone acetyltransferases (HATs) and histone deacetylases (HDACs) — results in transcriptional changes and also plays a critical role in cardiac development and disease. A new study shows that overexpression of the atypical transcriptional corepressor homeodomain-only protein (Hop) causes cardiac hypertrophy via recruitment of a class I HDAC. In contrast to the body of work on transcriptional mechanisms that drive cardiac hypertrophy, including class II HDACs, this report elucidates a novel growth-suppressing transcriptional pathway in cardiac muscle that opposes hypertrophic growth.

机译：组蛋白乙酰化受两种拮抗酶-组蛋白乙酰转移酶（HATs）和组蛋白脱乙酰酶（HDACs）的调节-导致转录变化，并且在心脏发育和疾病中也起着关键作用。一项新研究表明，非典型转录共加压因子仅同源异域域蛋白（Hop）的过表达通过募集I类HDAC导致心脏肥大。与驱动心脏肥大的转录机制（包括II类HDAC）的研究工作形成鲜明对比的是，该报告阐明了与肥大性生长相反的新型抑制心肌生长的转录途径。

著录项

作者
Hamamori, Yasuo; Schneider, Michael D.;
展开▼
作者单位

展开▼
年度 2003
总页数
原文格式 PDF
正文语种 en
中图分类

相似文献

外文文献
中文文献
专利

1. CKIP-1 inhibits cardiac hypertrophy by regulating class ii histone deacetylase phosphorylation through recruiting PP2A [J] . Circulation: An Official Journal of the American Heart Association . 2012,第25期

机译：CKIP-1通过募集PP2A调节ii类组蛋白脱乙酰基酶的磷酸化来抑制心脏肥大
2. CKIP-1 inhibits cardiac hypertrophy by regulating class ii histone deacetylase phosphorylation through recruiting PP2A [J] . Circulation: An Official Journal of the American Heart Association . 2012,第25期

机译：通过募集PP2A来调节II类组蛋白脱乙酰化酶磷酸化，CKIP-1抑制心脏肥大
3. Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy [J] . EomG.H., NamY.S., OhJ.G., Circulation research: a journal of the American Heart Association . 2014,第7期

机译：p300 / CBP相关因子/组蛋白脱乙酰基酶5对组蛋白脱乙酰基酶2的乙酰化的调节作用
4. MS Identification of A Redox-Dependent Pathway for Regulating Histone Deacetylase in Cardiac Myocytes [C] . Hong Li, Tong Liu, Tetsuro Ago, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：用于调节心肌细胞中组蛋白脱乙酰酶的氧化还原依赖性途径的MS鉴定
5. The role of class I histone deacetylases in the transcriptional repression of estrogen receptor in response to hyperactive map kinase signaling. [D] . Plotkin, Amy Jayne. 2014

机译：I类组蛋白脱乙酰基酶在反应过度活跃的图激酶信号传导中在雌激素受体的转录抑制中的作用。
6. HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy [O] . Yasuo Hamamori, Michael D. Schneider 2003

机译：跃升为HAT：募集I类组蛋白脱乙酰基酶可阻止与心脏肥大相对应的新型转录途径
7. Cardiac hypertrophy and histone deacetylase–dependent transcriptional repression mediated by the atypical homeodomain protein Hop [O] . Kook, Hyun, Lepore, John J., Gitler, Aaron D., 2003

机译：非典型同源域蛋白Hop介导的心肌肥大和组蛋白脱乙酰基酶依赖性转录抑制

HATs off to Hop: recruitment of a class I histone deacetylase incriminates a novel transcriptional pathway that opposes cardiac hypertrophy

摘要

著录项

相似文献

相关主题

期刊订阅